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ABSTRACT. Background: Tiredness is used in some characterizations of major depressive disorder (MDD). Transcranial magnetic stimulation (TMS) lowers all symptoms of MDD. Objective: To explore whether, 1) a visual analogue scale (VAS) for tiredness is a valid and reliable measure of a feature of MDD, and 2) TMS treatment reduces subjective tiredness occurring in MDD. Method: A naturalistic study of treatment with 10 Hz TMS. Completed pre- and post-treatment: HAMD-6, a visual analogue scale (VAS-6), the Clinical Global Impression – Severity (CGI-S) and a ‘VAS-tiredness’. Two groups received TMS. Acute course: N=52 participants suffering acute MDD, received 20 treatment courses (total courses 86). Relapse prevention (RP) course: N=26 participants suffering chronic relapsing MDD received scheduled episodic courses over 3 days; (total courses 266). VAS-tiredness scores were compared with the standardized tool results. Results: There were significant medium to large correlations between pre- and post-treatment VAS-tiredness and the standard depression measures (HAMD-6 .406 to .447, VAS-6 .446 to .525, CGI-S .348 to .407; all p<.001). TMS treatment produced a significant reduction in VAS-tiredness in both (Acute course and RP) groups (main effect: F(1,350)=147.3, p<.001, η2=.30). The two groups displayed difference in the pre-treatment VAS-tiredness with the Acute group having higher scores pre-treatment. Post-treatment tiredness scores were similar. Conclusion: VAS-tiredness is a valid measure of a feature of MDD. VAS-tiredness provides potentially useful information and complements standard mood tools. TMS treatment can reduce tiredness in MDD.

Keywords: VAS-tiredness; MDD; TMS treatment

How to cite: Pridmore, Saxby, Sheila Erger, Marzena Rybak, and Tamara May (2019). “Tiredness in Acute and Chronic Depression Treated with Transcranial Magnetic Stimulation,” American Journal of Medical Research 6(2): 7–18. doi:10.22381/AJMR6220191

Received 27 June 2019 • Received in revised form 6 August 2019
Accepted 6 August 2019 • Available online 8 August 2019

Saxby Pridmore
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School of Medicine, University of Tasmania,
Hobart, Tasmania, Australia;
TMS Department, Saint Helen’s Hospital,
Hobart, Tasmania, Australia
(corresponding author)
Sheila Erger
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TMS Department, Saint Helen’s Hospital,
Hobart, Tasmania, Australia
Marzena Rybak
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TMS Department, Saint Helen’s Hospital,
Hobart, Tasmania, Australia
Tamara May
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Department of Paediatrics and Education Research,
Monash University, Clayton, Australia

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